After gastric bypass surgery for obese, their insulin sensitivity improved as well as the pancreatic beta cell function. In gastric bypass operation there is severe negative energy balance.
Diabetes MellitusIt was thought that restricting calorie to a larger extent may also have similar effect on obese diabetics. Normally, an adult male is advised for intake of around 2000 calories per day. The experiment began by restricting calorie intake to 600 calories per day. Read more; http://clinispot.blogspot.com/2011/12/severe-energy-restriction-may-reverse.html